Cynthia Kenyon: Experiments that hint of longer lives
Why Hacker News recommends it
Listed among resources in longevity and anti-aging discussions as a key piece of lifespan research.
What it is
TED talk by biochemist Cynthia Kenyon on how a simple genetic mutation can double the lifespan of the worm C. elegans, and what that suggests about extending healthy human life.
Recommended by 0 HN commenters across 0 different months, 2015 to 2016.
What Hacker News said
Cites biomimic · 2015-03 · on “Ask HN: How would you solve mortality?”
See: [this video] and [LINK] To name some of the top roadblocks: - Cellular garbage collection - Inner-workings of Mitochondria and cell death/apoptosis at the wrong time. - DNA repair genes - Telomerase production/use Analyzing genomic pathways associated to these is key. Understanding why the expression of genes varies or decreases/increases at the wrong time is also key. Being able to use Cogntive computing/biomicry/AI/Machine Learning etc to analyze the hidden connections and relationships between phytochemicals, genes, proteins, pathways and environment is the next frontier. We're working on it and could certainly use additional crowdsourcing approaches.
Cites biomimic · 2015-03 · on “Google Ventures' Bill Maris Investing in Idea of Living to 500”
[LINK] [LINK] [LINK] [LINK] [LINK] See also: [this video] and [LINK] To name some of the top roadblocks: - Cellular garbage collection - Inner-workings of Mitochondria and cell death/apoptosis at the wrong time. - DNA repair genes - Telomerase production/use Analyzing genomic pathways associated to these is key. Understanding why the expression of genes varies or decreases/increases at the wrong time is also key. Being able to use Cogntive computing/biomicry/AI/Machine Learning etc to analyze the hidden connections and relationships between phytochemicals, genes, proteins, pathways and environment is the next frontier. We're working on it and could certainly use additional crowdsourcing approache
Cites meeper16 · 2015-05 · on “Russian Billionaire Dmitry Itskov Plans on Becoming Immortal by 2045”
Were almost near the starting line with research and companies like Human Longevity, CalicoLabs(Google,Genentech), GenoPharmix, Buck Institute, SENS Foundation and this: Cynthia Kenyon: Experiments that hint of longer [this video] Epigentics and extending human lifespan: [LINK]
Cites KasianFranks · 2016-01 · on “Ask HN: What should we fund at YC Research?”
AI applied to understanding the hidden relationships linking epigentics and extending human lifespan via algorithmically engineered diet, nutrition and longevity genomics: The precedent: Laura Deming: Making a business out of fighting the ills of aging [LINK] Cynthia Kenyon: Experiments that hint of longer lives (Cynthia now works at Google's Calico Labs) [this video] Now connect this: Nutrigenomics, Epigenetics, and Stress Tolerance [LINK] Now combine with: What is Epigenetics? with Nessa Carey The last 10mins are very important, in particular minute 35:06 [LINK] Statistical modeling of biomedical corpora: mining the Caenorhabditis Genetic Center Bibliography for genes related to life span - Ble