Anton: A Special-Purpose Machine That Achieves a Hundred-Fold Speedup in Biomolecular Simulations

What Hacker News said

Strong rec max_ · 2025-06 · on “A Primer on Molecular Dynamics”

There is brilliant video by the hedge fund manager DE Shaw about molecular dynamics simulation. Its very accessible and I found it very interesting — [this video]

Cites cma · 2014-01 · on “AMD launches Kaveri processors aimed at starting a computing revolution”

I'm not giving you what you want, but here's a visual example of using a computational microscope to understand how drug actually works and finds its binding site: [this video] If you can't see a difference between that and say, X-Ray crystallography then well..

Cites conformist · 2020-11 · on “David Shaw vs. Seymour Papert Debate (1995) [video]”

There are also some more recent academic talks of his on youtube, mostly focused on his bio-informatics research. E.g. [this video]

Cites max_ · 2024-01 · on “Ask HN: What's a promising area to work on in 2024 -ideally not crowded already?”

> What do you mean by fundamental AI research? Coming up with new/original models that solve the same exact problems that people are trying to solve with neural networks (computer vision, language translation, image generation etc) hopefully that are better performing & cheaper computationally. > What kind of computational model? I think answering that question would be what the researcher in this field is trying todo. I think a place to start would be exploring abandoned AI strategies like Genetics Algorithms & Markov Logic >What are some practical applications of complex systems? - Modeling Financial Markets [1] - Drug discovery via Molecular Dynamics Simulations [2] - Urban Planning [3] -