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Cites holopol · 2020-04 · on “Our Long Bets and Predictions about 02020”

While the analyses above suggest that SARS-CoV-2 may bind human ACE2 with high affinity, computational analyses predict that the interaction is not ideal7 and that the RBD sequence is different from those shown in SARS-CoV to be optimal for receptor binding. Thus, the high-affinity binding of the SARS-CoV-2 spike protein to human ACE2 is most likely the result of natural selection on a human or human-like ACE2 that permits another optimal binding solution to arise. This is strong evidence that SARS-CoV-2 is not the product of purposeful manipulation. [LINK] concludes that since maybe (because computational analysis) it isn't as efficient for the receptor binding it wasn't purposefully manipu

Cites jnbiche · 2020-04 · on “Our Long Bets and Predictions about 02020”

Your assertion was, "At the very least, proponent of this theory should be able to provide evidence that bats or viral samples from bats were present in the lab before the outbreak". Yes, it's clear they were working with live bats of the species that most scientists, even those who believe in the pangolin hypothesis, believe is the natural reservoir of SARS-CoV-2. Multiple papers published from BOTH Wuhan labs describe such bat research. The Wuhan CDC did so much live animal research that they employed collections expert by the name of Tian Jun-Hua, whose work collecting bats is described in a number of pre-pandemic media reports (including several times he quarantined himself after being e

Cites gridlockd · 2020-05 · on “Wuhan lab did research on bat viruses, but no evidence of accidental release”

> I'm not sure who you're quoting, but it's not me. Indeed, I oversaw that it was "yorwba" who put that comment into "our" thread, not you. My apologies. > As for the claim that the Wuhan cdc is tight next to the seafood market, I direct you to this comment: [LINK] which thoroughly and completely debunks those claims. That's not a "thorough and complete" debunking, that's an erroneous assessment regarding the functions and location(s) of the Wuhan CDC, based on a cursory glance at websites. A little bit more research would've revealed that the Wuhan CDC indeed was performing experiments on bats and that it has several facilities (including one near the seafood market). [this video] [LINK]

Cites gridlockd · 2020-05 · on “Wuhan lab did research on bat viruses, but no evidence of accidental release”

> If you search on Google Maps for the Wuhan Centers for Disease Prevention and Control, you instead find a building about 1.5 km from the seafood market. There is not just one building, this is the one mentioned: [LINK] Remember that Google is effectively not operating in China anymore, so their information is bound to be outdated and incomplete. > But further, when I look at the web page of the WHCDC, it looks like they're mainly a community health institution, not a research institute. The people studying coronaviruses are 15 km away, in the Wuhan Institute of Virology. Scientists at the Wuhan CDC are studying live bats and bat coronaviruses: [this video]

Cites voldacar · 2022-04 · on ““This shouldn’t happen”: Inside the virus-hunting nonprofit EcoHealth Alliance”

I had a longer response but my browser crashed so I'll just try to summarize my thoughts. Our disagreement basically comes down to how we assign priors. I'm not really sure how productive a debate on priors can be because it's not like there are a bunch of previous similar scenarios that we can study in detail. On P(WIV leak): Wikipedia[0] lists 50 lab leaks (or more precisely, failure of lab biosecurity measures) in the past century. The actual number is probably much higher because people and institutions like to hide their mistakes. So the base probability of a lab leak happening from a lab that studies pathogens is only moderately low to begin with. But P(WIV leak) is probably significan

Cites mikeyouse · 2022-06 · on “What happened to the lab-leak hypothesis?”

Yes, the WIV does indeed study the bats that we're questioning. I'm not sure what point you're trying to make? The claim you're questioning is "There are horseshoe bats near Wuhan". Do you think they just invented the bats? I mean... they're on video... [this video]